The Bauer Research Foundation (BRF) was established to serve as a resource to pet owners with pets afflicted with cancer.
The BRF has responded to more than 2,500 inquiries from pet owners since its inception in 2009 and will continue to be a voice for change.
Pet Owner's may submit questions or concerns by selecting the "Contact Us" tab.
BREAKING NEWS:
APRIL 2012
BRF receives a grant from the WINN Feline Foundation to screen cats to assess eligibility for vitamin B12-based therapies and diagnostic imaging. (Click on the link below for more information.)
January 2012
BRF receives a grant from the American Kennel Club Canine Health Foundation to screen dogs to assess eligiblity for vitamin B12-based therapies. (Click on link below for more information)
The goal of the BRF is to use the data from the Canine Health Foundation and the WINN Feline Foundation to apply to the Food and Drug Administration to evaluate the efficacy of NO-Cbl, a vitamin B12-based compound, in companion animals.
Help the BRF to continue its mission
by making a donation today!
The Bauer Research Foundation (BRF) has been granted 501(c)(3) exemption by the Internal Revenue Service and is classified as a public charity.
The BRF is qualified to receive tax deductible contributions under section 170 of the Code. The BRF is also qualified to receive tax deductible bequests, devises, transfers or gifts under section 2055, 2106, or 2522 of the Code.
Donations can be made on-line using the "Donate" tab above or by downloading the Pledge form and mailing your donation to the BRF directly.
IN THE NEWS:
2011: Dr. Bauer receives an Outstanding Achievement Award from Walsh University
2010: Pets to humans: looking for a cure (refer to page 25)
2009: Read the first, formal research studies evaluating NO-Cbl in dogs:
The first dog was treated with NO-Cbl more than five years ago. Diagnosed with an extremely aggressive form of cancer called anal sac adenocarcinoma, Oscar’s future seemed bleak. Bedridden and unresponsive to chemotherapy or radiation, he would be lucky to survive three months. But thanks to NO-Cbl, Oscar’s cancer receded and he was walking again within two weeks.
Specifically, Dr. Bauer developed a vitamin B12 -based compound, nitrosylcobalamin (NO-Cbl), (United States Patent # 5,936,082) at the University of Akron, Akron, Ohio.
NO-Cbl is a derivative of vitamin B12 that occurs in nature. Several human and animal studies have shown that vitamin B12 (hydroxocobalamin) will scavenge nitric oxide naturally in vivo.
Research on NO-Cbl spans more than 10 years and includes 6 publications in peer-reviewed scientific journals:
•Bauer JA, Frye, G, Bahr A, Gieg J, Brofman P: In vivo anti-tumor effects of nitrosylcobalamin (NO-Cbl) against anal sac adenocarcinoma: a case study. 2010 Invest New Drugs, 28:694-702
•Bauer JA, Lupica JA, Schmidt H, Morrison BH, Haney RM, Masci RK, Lee RM, DiDonato JA, Lindner DJ: Nitrosylcobalamin potentiates the anti-neoplastic effects of chemotherapeutic agents via suppression of survival signaling. PLoS ONE 20072: e1313
•Tang Z, Bauer JA, Morrison BH, Lindner DJ. Nitrosylcobalamin promotes cell death via S-nitrosylation of Apo2L/TRAIL receptor DR4. Molecular and Cellular Biology2006; 26(15):5588-94.
•Bauer JA et al. Suppression of NF-kB survival signaling by nitrosylcobalamin sensitizes neoplasms to the anti-tumor effects of Apo2L/TRAIL. Journal of Biological Chemistry. 2003; 278: 39461-39469.
•Bauer JA, Morrison BH, Grane RW, Jacobs BS, Dabney S, Gamero AM, Carnevale KA, Smith DJ, Drazba J, Seetharam B, Lindner DJ: Effects of interferon-beta on transcobalamin II-receptor expression and antitumor activity of nitrosylcobalamin. Journal of the National Cancer Institute. 2002; 94: 1010-1019.
•Bauer, J.A.: Synthesis, characterization, and nitric oxide release profile of nitrosylcobalamin: a potential chemotherapeutic agent. AntiCancer Drugs. 1998; 9(3): 239-244.
IMPORTANT SURVEY:
Pet Owners!!! We are conducting a 5-question survey to help increase our chances to help provide NO-Cbl for veterinary use. Your help is needed to answer some simple questions. Please click on the link below.
Currently, the Bauer Research Foundation is working to obtain FDA approval for NO-Cbl, a vitamin B12 derivative (shown to occur naturally in animals). Our Chief Veterinary Officer is Dr. Annette Sysel (refer to the About Us tab for more information).
Background on Nitric Oxide Donors
NO-Cbl is in the family of compounds known as nitric oxide (NO) donors. NO has been shown to kill cancer cells in vitro and in vivo by numerous research groups across the world. Two of the earliest NO donors, glyceryl trinitrate (GTN) and sodium nitroprusside (SNP) have been around since the 1800s. GTN was first used in humans to treat angina since the 1870s. SNP was first used in humans in 1928. As both GTN and SNP produce NO, the biochemical basis exists that these compounds can be utilized to fight cancer. Both compounds are commercially available. A drawback to the use of conventional NO donors is that they lack tumor targeting and if administered systemically would lead to hypotension. However, these compounds may be used to deliver NO to tumors but would require injecting the compounds directly into the tumor. A drawback of SNP is cyanide production which can be de-toxified by the liver. Information about these compounds and their experimental use in possibly treating cancer can be found at www.pubmed.gov or by searching Google. Please consult your veterinarian for advice and possible treatment options.
Dr. Dongho Seo is a licensed veterinarian that is familiar with using SNP to treat canine tumors using a trans-dermal rub (goes thru the skin). He practices at Smith Ridge Veterinary Clinic http://www.smithridge.com/. Dr. Seo can be contacted at drseosmithridge@gmail.com
Alternative Treatment Options
Please consult with your veterinary as side-effects are not known.
1. Inositol combined with Inositol hexaphosphate has been to shown to have anti-cancer properties http://ip-6.net/secondpage.html This can be added to drinking water.
3. Green tea can be added to the drinking water as well. A search of www.pubmed.gov of "green tea and cancer" produces more than 3000 references. Green tea has at least two known components that have anti-cancer properties. Or a green tea extract can be added to the drinking water to avoid caffeine. Japanese Matcha tea is a good source for these extracts.
It is important to understand that because of the complexities of cancer, no single agent including NO-Cbl, will ever be "the cure" for cancer. The cure for cancer will be achieved by a combination of many factors including dietary considerations, compounds that prevent blood supply to tumors (anti-angiogenic), biological therapies such as interferons and TRAIL, immune system modulators, traditional cytotoxic agents, radiation, and targeted therapies such as histone deacetylase inhibitors, tyrosine kinase inhibitors, and anti-tumor vaccines to name a few.
ADDITIONAL RESOURCES FOR PET OWNERS:
Information on ACTIVE CLINICAL TRIALS for CATS and DOGS:
The information contained in this website is intended to supplement, not substitute for,the expertise and judgment of your veterinarian. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that the use of NO-Cbl or any compound, natural or synthetic, in treating your pet is safe, appropriate or effective. NO-Cbl has not been approved or tested by the Food and Drug Administration or the Center for Veterinary Medicine.
